Association of candidate gene polymorphisms with diabetic retinopathy in Chinese patients with type 2 diabetes.

Association of candidate gene polymorphisms with diabetic retinopathy in Chinese patients with type 2 diabetes.

To investigate the relationship between a set of six candidate genes and the risk of diabetic retinopathy (DR) in a cohort of Chinese patients town community with type 2 diabetes mellitus (T2DM).


METHOD
A population-based cross-sectional study. Diabetic subjects were recruited from the urban community in Beijing and categorized into groups of proliferative diabetic retinopathy (PDR), non-proliferative diabetic retinopathy (NPDR), or diabetes without retinopathy (DWR) by fundus photography and duration of diabetes.

Six candidate genes, including glycation end certain products receptor sophisticated (AGER), aldose reductase (AKR1B1), inducible nitric oxide synthase (iNOS), pigment epithelium derived factor (PEDF), tumor necrosis factor-alpha (TNF-α), and paraoxonase 1 (PON1), selected by Meta-analysis of genetic association study for DR and biochemical pathways involved in the development of DR. Allele and genotype distribution of 21 functional single nucleotide polymorphisms (SNPs) in their six candidate genes were investigated using the genotype MassARRAY system.


RESULTS
Among the 1461 patients with diabetes were recruited from the community, 569 have been selected in the following genotypic analysis, including 97 patients with PDR, with NPDR 217, and 255 with DWR. For promoter variant rs1051993 in AGER gene, allele and genotype distribution in PDR group differ from those in the group DWR (allele: P = 0.011; genotype: P = 0.01).

Compared with DWR, patients with PDR had a lower frequency of heterozygous genotype GT (9.8% for DWR, 1% for PDR, OR: 0.10, 95% CI: 0.01 to 0.72) and minor alleles T (4.9% for DWR, 0.5% for PDR, OR: 0.10, 95% CI: 0.01 to 0.75). In the multivariate model, the distribution of genotypes of rs1051993 in PDR group were significantly different from those in the group DWR (GT vs GG: OR: 0.07, 95% CI: 0.01 to 0.61, P <0.001). No association with DR SNP observed in other genotypes.


CONCLUSION
The data showed a significant association of rs1051993 variant in the gene promoter AGER with PDR in the Chinese group with type 2 diabetes.

 Association of candidate gene polymorphisms with diabetic retinopathy in Chinese patients with type 2 diabetes.
Association of candidate gene polymorphisms with diabetic retinopathy in Chinese patients with type 2 diabetes.

Sector retinitis pigmentosa: Report of ten cases and review of the literature.

To describe the genotypic and phenotypic ten patients with retinitis pigmentosa sector (RP). We also review previously reported mutations associated with RP sector and provide discussions about possible underlying pathophysiological mechanisms.

Patients underwent detailed ophthalmological examination, fundus photography, fundus autofluorescence (FAF) imaging, spectral-domain optical coherence tomography (SD-OCT), as well as visual field and electroretinographic testing. All patients underwent a genetic test to identify the molecular etiology of their disease.


result
A total of ten patients studied. Among these patients, nine had mutations in RHO (c.677T> C; p.Leu226Pro (Novel), c.68C> A; p.Pro23His, c.808A> C; p.Ser270Arg, c.44A> G; p .Asn15Ser, and c.325G> A; p.Gly109Arg), and one patient had a mutation in RPGR (c.3092_3093delAG; p.Glu1031Glyfs * 47). All patients with missense mutations in RHO have visual acuities (VAS) better than 20/30 and showed sustained ellipsoid zone retinal foveal and topped structure.

Patients with deletion c.3092_3093delAG in RPGR have a VA of 20/60 oculus dexter (OD) and the 20/400 oculus sinister (OS), as well as significant foveal contour thinning and atrophy. All patients showed changes in pigment, or marked atrophy along the lower arcade, or both. This pattern of degeneration associated with visual disabilities and hyperFAF and superior hypo.

p73 antibody

70R-37515 100 ug
EUR 327.6
Description: Rabbit Polyclonal p73 antibody

p73 antibody

70R-33698 100 ug
EUR 392.4
Description: Rabbit polyclonal p73 antibody

p73 antibody

70R-34351 100 ug
EUR 392.4
Description: Rabbit polyclonal p73 antibody

p73 antibody

70R-50511 100 ul
EUR 344.4
Description: Purified Polyclonal p73 antibody

p73 antibody

70R-50512 100 ul
EUR 292.8
Description: Purified Polyclonal p73 antibody

p73 Antibody

ABF0322 100 ug
EUR 525.6

p73 Antibody

ABF5465 100 ug
EUR 525.6

p73 Antibody

ABF6015 100 ug
EUR 525.6

p73 Antibody

AF0322 200ul
EUR 420

p73 antibody

20R-1924 50 ug
EUR 337.2
Description: Rabbit polyclonal p73 antibody

p73 antibody

20R-2256 50 ug
EUR 337.2
Description: Rabbit polyclonal p73 antibody

p73 Antibody

33579-100ul 100ul
EUR 302.4

p73 Antibody

33579-50ul 50ul
EUR 224.4

p73 Antibody

AF5465 200ul
EUR 420

p73 Antibody

AF6015 200ul
EUR 420

p73 Antibody

20-abx008608
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

p73 Antibody

F51407-0.4ML 0.4 ml
EUR 322.15
Description: TP73 is tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each other's promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors.

p73 Antibody

R31648 100 ug
EUR 356.15
Description: Tumor protein 73(TP73), encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It is mapped to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Furthermore, recent finding are suggesting that over-expression of transcription factors involved in cell cycle regulation and synthesis of DNA in mammalian cells (e.g.: E2F-1) induces the expression of the protein. In addition, p73 is a substrate of the c-Abl kinase and that the ability of c-Abl to phosphorylate it is markedly increased by gamma-irradiation.

p73 (pT86) Antibody

abx219067-100ug 100 ug
EUR 526.8

p73 (pT99) Antibody

20-abx009875
  • EUR 376.80
  • EUR 560.40
  • EUR 243.60
  • 100 ul
  • 200 ul
  • 30 ul

p73 (pY99) Antibody

abx011313-100ug 100 ug
EUR 526.8

p73 antibody (Tyr99)

70R-37139 100 ug
EUR 418.8
Description: Rabbit Polyclonal p73 antibody (Tyr99)

p73 antibody (Tyr99)

70R-34350 100 ug
EUR 392.4
Description: Rabbit polyclonal p73 antibody (Tyr99)

p73 (pS388) Antibody

abx219068-100ug 100 ug
EUR 526.8

p73 Blocking Peptide

AF0322-BP 1mg
EUR 234

p73 Blocking Peptide

20-abx063387
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

p73 Blocking Peptide

AF5465-BP 1mg
EUR 234

p73 Blocking Peptide

AF6015-BP 1mg
EUR 234

p73 Polyclonal Antibody

ABP52141-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of p73 from Human, Mouse. This p73 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p73 around the non-phosphorylation site of Y99

p73 Polyclonal Antibody

ABP52141-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of p73 from Human, Mouse. This p73 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p73 around the non-phosphorylation site of Y99

p73 Polyclonal Antibody

ABP52141-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of p73 from Human, Mouse. This p73 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p73 around the non-phosphorylation site of Y99

p73 Polyclonal Antibody

ABP56441-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of p73 from Human. This p73 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human p73 at AA range: 240-320

p73 Polyclonal Antibody

ABP56441-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of p73 from Human. This p73 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human p73 at AA range: 240-320

p73 Polyclonal Antibody

ABP56441-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of p73 from Human. This p73 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human p73 at AA range: 240-320

p73 Polyclonal Antibody

ABP53074-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of p73 from Human. This p73 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p73 around the non-acetylation site of K321

p73 Polyclonal Antibody

ABP53074-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of p73 from Human. This p73 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p73 around the non-acetylation site of K321

p73 Polyclonal Antibody

ABP53074-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of p73 from Human. This p73 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p73 around the non-acetylation site of K321

p73 Polyclonal Antibody

ABP53075-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of p73 from Human, Mouse, Rat. This p73 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p73 around the non-acetylation site of K327

p73 Polyclonal Antibody

ABP53075-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of p73 from Human, Mouse, Rat. This p73 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p73 around the non-acetylation site of K327

p73 Polyclonal Antibody

ABP53075-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of p73 from Human, Mouse, Rat. This p73 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p73 around the non-acetylation site of K327

p73 Polyclonal Antibody

41736-100ul 100ul
EUR 302.4

p73 Polyclonal Antibody

41736-50ul 50ul
EUR 224.4

p73 Polyclonal Antibody

41737-100ul 100ul
EUR 302.4

p73 Polyclonal Antibody

41737-50ul 50ul
EUR 224.4

p73 Polyclonal Antibody

41319-100ul 100ul
EUR 302.4

p73 Polyclonal Antibody

41319-50ul 50ul
EUR 224.4

p73 Conjugated Antibody

C48918 100ul
EUR 476.4

p73 Polyclonal Antibody

ES7440-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against p73 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p73 Polyclonal Antibody

ES7440-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against p73 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p73 Polyclonal Antibody

ES4073-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against p73 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p73 Polyclonal Antibody

ES4073-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against p73 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p73 Polyclonal Antibody

ES4074-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against p73 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

p73 Polyclonal Antibody

ES4074-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against p73 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

p73 Polyclonal Antibody

ES3140-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against p73 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

p73 Polyclonal Antibody

ES3140-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against p73 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

p73 (Ab-99) Antibody

21075-100ul 100ul
EUR 302.4

p73 (Ab-99) Antibody

21075-50ul 50ul
EUR 224.4

p73 (pY99) Blocking Peptide

20-abx063386
  • EUR 376.80
  • EUR 610.80
  • 1 mg
  • 5 mg

p73 (Phospho- Thr86) Antibody

ABF8296 100 ug
EUR 525.6

Phospho- p73 (Tyr99) Antibody

ABF3015 100 ug
EUR 525.6

p73 (Phospho- Ser388) Antibody

ABF8500 100 ug
EUR 525.6

p73 (Phospho-Tyr99) Antibody

11058-100ul 100ul
EUR 302.4

p73 (Phospho-Tyr99) Antibody

11058-50ul 50ul
EUR 224.4

p73 (Phospho-Thr86) Antibody

12622-100ul 100ul
EUR 302.4

p73 (Phospho-Thr86) Antibody

12622-50ul 50ul
EUR 224.4

p73 (Phospho-Ser388) Antibody

12772-100ul 100ul
EUR 302.4

p73 (Phospho-Ser388) Antibody

12772-50ul 50ul
EUR 224.4

p73 recombinant monoclonal antibody

A5272 100ul X 3
EUR 714
Description: A recombinant monoclonal antibody from rabbit against human p73 for WB, IHC,ELISA

p73 Antibody / Tumor Protein 73

RQ4726 100ul
EUR 356.15
Description: The TP73 encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [RefSeq]

Antibody for Human p73 (pTyr99)

SPC-1413D 0.1ml
EUR 424.8
Description: A polyclonal antibody for p73 (pTyr99) from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human p73 around the phosphorylation site of tyrosine 99 (pTyr99).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This p73 (pTyr99) antibody is unconjugated.

Antibody for Human p73 (pTyr99)

SPC-1413D-A390 0.1ml
EUR 481.2
Description: A polyclonal antibody for p73 (pTyr99) from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human p73 around the phosphorylation site of tyrosine 99 (pTyr99).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This p73 (pTyr99) antibody is conjugated to ATTO 390.

Antibody for Human p73 (pTyr99)

SPC-1413D-A488 0.1ml
EUR 480
Description: A polyclonal antibody for p73 (pTyr99) from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human p73 around the phosphorylation site of tyrosine 99 (pTyr99).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This p73 (pTyr99) antibody is conjugated to ATTO 488.

Antibody for Human p73 (pTyr99)

SPC-1413D-A565 0.1ml
EUR 480
Description: A polyclonal antibody for p73 (pTyr99) from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human p73 around the phosphorylation site of tyrosine 99 (pTyr99).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This p73 (pTyr99) antibody is conjugated to ATTO 565.

Antibody for Human p73 (pTyr99)

SPC-1413D-A594 0.1ml
EUR 480
Description: A polyclonal antibody for p73 (pTyr99) from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human p73 around the phosphorylation site of tyrosine 99 (pTyr99).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This p73 (pTyr99) antibody is conjugated to ATTO 594.

Antibody for Human p73 (pTyr99)

SPC-1413D-A633 0.1ml
EUR 480
Description: A polyclonal antibody for p73 (pTyr99) from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human p73 around the phosphorylation site of tyrosine 99 (pTyr99).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This p73 (pTyr99) antibody is conjugated to ATTO 633.

Antibody for Human p73 (pTyr99)

SPC-1413D-A655 0.1ml
EUR 480
Description: A polyclonal antibody for p73 (pTyr99) from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human p73 around the phosphorylation site of tyrosine 99 (pTyr99).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This p73 (pTyr99) antibody is conjugated to ATTO 655.

Antibody for Human p73 (pTyr99)

SPC-1413D-A680 0.1ml
EUR 480
Description: A polyclonal antibody for p73 (pTyr99) from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human p73 around the phosphorylation site of tyrosine 99 (pTyr99).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This p73 (pTyr99) antibody is conjugated to ATTO 680.

Antibody for Human p73 (pTyr99)

SPC-1413D-A700 0.1ml
EUR 480
Description: A polyclonal antibody for p73 (pTyr99) from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human p73 around the phosphorylation site of tyrosine 99 (pTyr99).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This p73 (pTyr99) antibody is conjugated to ATTO 700.

Antibody for Human p73 (pTyr99)

SPC-1413D-ALP 0.1ml
EUR 472.8
Description: A polyclonal antibody for p73 (pTyr99) from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human p73 around the phosphorylation site of tyrosine 99 (pTyr99).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This p73 (pTyr99) antibody is conjugated to Alkaline Phosphatase.

Antibody for Human p73 (pTyr99)

SPC-1413D-APC 0.1ml
EUR 478.8
Description: A polyclonal antibody for p73 (pTyr99) from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human p73 around the phosphorylation site of tyrosine 99 (pTyr99).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This p73 (pTyr99) antibody is conjugated to APC .

Antibody for Human p73 (pTyr99)

SPC-1413D-APCCY7 0.1ml
EUR 565.2
Description: A polyclonal antibody for p73 (pTyr99) from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human p73 around the phosphorylation site of tyrosine 99 (pTyr99).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This p73 (pTyr99) antibody is conjugated to APC/Cy7.

Antibody for Human p73 (pTyr99)

SPC-1413D-BI 0.1ml
EUR 475.2
Description: A polyclonal antibody for p73 (pTyr99) from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human p73 around the phosphorylation site of tyrosine 99 (pTyr99).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This p73 (pTyr99) antibody is conjugated to Biotin.

Antibody for Human p73 (pTyr99)

SPC-1413D-DY350 0.1ml
EUR 496.8
Description: A polyclonal antibody for p73 (pTyr99) from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human p73 around the phosphorylation site of tyrosine 99 (pTyr99).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This p73 (pTyr99) antibody is conjugated to Dylight 350.

Antibody for Human p73 (pTyr99)

SPC-1413D-DY405 0.1ml
EUR 483.6
Description: A polyclonal antibody for p73 (pTyr99) from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human p73 around the phosphorylation site of tyrosine 99 (pTyr99).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This p73 (pTyr99) antibody is conjugated to Dylight 405.

Antibody for Human p73 (pTyr99)

SPC-1413D-DY488 0.1ml
EUR 471.6
Description: A polyclonal antibody for p73 (pTyr99) from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human p73 around the phosphorylation site of tyrosine 99 (pTyr99).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This p73 (pTyr99) antibody is conjugated to Dylight 488.

Antibody for Human p73 (pTyr99)

SPC-1413D-DY594 0.1ml
EUR 474
Description: A polyclonal antibody for p73 (pTyr99) from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human p73 around the phosphorylation site of tyrosine 99 (pTyr99).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This p73 (pTyr99) antibody is conjugated to Dylight 594.

Antibody for Human p73 (pTyr99)

SPC-1413D-DY633 0.1ml
EUR 468
Description: A polyclonal antibody for p73 (pTyr99) from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human p73 around the phosphorylation site of tyrosine 99 (pTyr99).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This p73 (pTyr99) antibody is conjugated to Dylight 633.

Antibody for Human p73 (pTyr99)

SPC-1413D-FITC 0.1ml
EUR 470.4
Description: A polyclonal antibody for p73 (pTyr99) from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human p73 around the phosphorylation site of tyrosine 99 (pTyr99).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This p73 (pTyr99) antibody is conjugated to FITC.

Antibody for Human p73 (pTyr99)

SPC-1413D-HRP 0.1ml
EUR 465.6
Description: A polyclonal antibody for p73 (pTyr99) from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human p73 around the phosphorylation site of tyrosine 99 (pTyr99).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This p73 (pTyr99) antibody is conjugated to HRP.

Antibody for Human p73 (pTyr99)

SPC-1413D-P594 0.1ml
EUR 488.4
Description: A polyclonal antibody for p73 (pTyr99) from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human p73 around the phosphorylation site of tyrosine 99 (pTyr99).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This p73 (pTyr99) antibody is conjugated to PE/ATTO 594.

Antibody for Human p73 (pTyr99)

SPC-1413D-PCP 0.1ml
EUR 478.8
Description: A polyclonal antibody for p73 (pTyr99) from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human p73 around the phosphorylation site of tyrosine 99 (pTyr99).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This p73 (pTyr99) antibody is conjugated to PerCP.

Antibody for Human p73 (pTyr99)

SPC-1413D-RPE 0.1ml
EUR 476.4
Description: A polyclonal antibody for p73 (pTyr99) from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human p73 around the phosphorylation site of tyrosine 99 (pTyr99).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This p73 (pTyr99) antibody is conjugated to RPE .

Antibody for Human p73 (pTyr99)

SPC-1413D-STR 0.1ml
EUR 477.6
Description: A polyclonal antibody for p73 (pTyr99) from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human p73 around the phosphorylation site of tyrosine 99 (pTyr99).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This p73 (pTyr99) antibody is conjugated to Streptavidin.

p73 Antibody / Tumor Protein 73

V8089-100UG 100 ug
EUR 349.3
Description: The p53 gene is a widely studied anti-oncogene, or tumor suppressor gene. The p53 gene product can act as a negative regulator of cell growth in response to DNA damage. Mutations and allelic loss of the p53 gene have been associated with malignant transformation in a wide variety of human tumors. p53 shares considerable sequence similarity with p73, a gene that maps to a region in chromosome 1 that is frequently deleted in neuroblastomas. However, p73 does not appear to be activated by DNA damaging agents.

p73 Antibody / Tumor Protein 73

V8089-20UG 20 ug
EUR 153.3
Description: The p53 gene is a widely studied anti-oncogene, or tumor suppressor gene. The p53 gene product can act as a negative regulator of cell growth in response to DNA damage. Mutations and allelic loss of the p53 gene have been associated with malignant transformation in a wide variety of human tumors. p53 shares considerable sequence similarity with p73, a gene that maps to a region in chromosome 1 that is frequently deleted in neuroblastomas. However, p73 does not appear to be activated by DNA damaging agents.

p73 Antibody / Tumor Protein 73

V8089SAF-100UG 100 ug
EUR 349.3
Description: The p53 gene is a widely studied anti-oncogene, or tumor suppressor gene. The p53 gene product can act as a negative regulator of cell growth in response to DNA damage. Mutations and allelic loss of the p53 gene have been associated with malignant transformation in a wide variety of human tumors. p53 shares considerable sequence similarity with p73, a gene that maps to a region in chromosome 1 that is frequently deleted in neuroblastomas. However, p73 does not appear to be activated by DNA damaging agents.

Tumor Protein P73 (TP73) Antibody

20-abx212029
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Tumor Protein P73 (TP73) Antibody

20-abx212030
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Tumor Protein P73 (TP73) Antibody

20-abx325464
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Tumor Protein P73 (TP73) Antibody

20-abx327414
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Tumor Protein P73 (TP73) Antibody

20-abx327493
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Tumor Protein P73 (TP73) Antibody

20-abx323526
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Tumor Protein P73 (TP73) Antibody

20-abx323607
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Tumor Protein P73 (TP73) Antibody

20-abx324682
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

p73 (Ab-99) Conjugated Antibody

C21075 100ul
EUR 476.4

Tumor Protein P73 (TP73) Antibody

abx037215-100ug 100 ug
EUR 469.2

Tumor Protein P73 (TP73) Antibody

20-abx005990
  • EUR 493.20
  • EUR 710.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 50 ul

Tumor Protein P73 (TP73) Antibody

abx034143-400ul 400 ul
EUR 627.6

Tumor Protein P73 (TP73) Antibody

abx034143-80l 80 µl
EUR 343.2

Tumor Protein P73 (TP73) Antibody

abx332222-100ul 100 ul
EUR 510

p73 (Acetyl Lys321) Polyclonal Antibody

ABP50113-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of p73 Acetyl Lys321) from Human. This p73 Acetyl Lys321) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the human p73 around the acetylation site of K321

p73 (Acetyl Lys321) Polyclonal Antibody

ABP50113-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of p73 Acetyl Lys321) from Human. This p73 Acetyl Lys321) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the human p73 around the acetylation site of K321

p73 (Acetyl Lys321) Polyclonal Antibody

ABP50113-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of p73 Acetyl Lys321) from Human. This p73 Acetyl Lys321) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the human p73 around the acetylation site of K321

p73 (Acetyl Lys327) Polyclonal Antibody

ABP50114-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of p73 Acetyl Lys327) from Human, Mouse, Rat. This p73 Acetyl Lys327) antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the human p73 around the acetylation site of K327

p73 (Acetyl Lys327) Polyclonal Antibody

ABP50114-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of p73 Acetyl Lys327) from Human, Mouse, Rat. This p73 Acetyl Lys327) antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the human p73 around the acetylation site of K327

p73 (Acetyl Lys327) Polyclonal Antibody

ABP50114-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of p73 Acetyl Lys327) from Human, Mouse, Rat. This p73 Acetyl Lys327) antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the human p73 around the acetylation site of K327

p73 (phospho Tyr99) Polyclonal Antibody

ABP50392-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of p73 phospho Tyr99) from Human, Mouse. This p73 phospho Tyr99) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p73 around the phosphorylation site of Y99

p73 (phospho Tyr99) Polyclonal Antibody

ABP50392-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of p73 phospho Tyr99) from Human, Mouse. This p73 phospho Tyr99) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p73 around the phosphorylation site of Y99

p73 (phospho Tyr99) Polyclonal Antibody

ABP50392-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of p73 phospho Tyr99) from Human, Mouse. This p73 phospho Tyr99) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p73 around the phosphorylation site of Y99

p73 (phospho Tyr99) Polyclonal Antibody

ES1391-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against p73 (phospho Tyr99) from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p73 (phospho Tyr99) Polyclonal Antibody

ES1391-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against p73 (phospho Tyr99) from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p73 (Acetyl Lys321) Polyclonal Antibody

ES1112-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against p73 (Acetyl Lys321) from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p73 (Acetyl Lys321) Polyclonal Antibody

ES1112-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against p73 (Acetyl Lys321) from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p73 (Acetyl Lys327) Polyclonal Antibody

ES1113-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against p73 (Acetyl Lys327) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

p73 (Acetyl Lys327) Polyclonal Antibody

ES1113-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against p73 (Acetyl Lys327) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

Tumor Protein p73 (TP73) ELISA Kit

abx596529-96tests 96 tests
EUR 867.6

Anti-p73 antibody

STJ94925 200 µl
EUR 236.4
Description: Rabbit polyclonal to p73.

Anti-p73 antibody

STJ94926 200 µl
EUR 236.4
Description: Rabbit polyclonal to p73.

Anti-p73 antibody

STJ96708 200 µl
EUR 236.4
Description: Rabbit polyclonal to p73.

Anti-p73 antibody

STJ96709 200 µl
EUR 236.4
Description: Rabbit polyclonal to p73.

p73 DNA-Binding ELISA Kit (OKAG00430)

OKAG00430 96 Wells
EUR 903.6
Description: Description of target: This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined.;Species reactivity: Human, Mouse, Rat;Application: ELISA;Assay info: Assay Type: Qualitative DNA Binding ELISA ;Sensitivity:

Polyclonal TP73 / p73 Antibody (aa75-125)

APR02480G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TP73 / p73 (aa75-125). This antibody is tested and proven to work in the following applications:

p73 Colorimetric Cell-Based ELISA Kit

EKC1433 100ul
EUR 686.4

Polyclonal TP73 / p73 Antibody (aa271-320)

APR02841G 0.05ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TP73 / p73 (aa271-320). This antibody is tested and proven to work in the following applications:

Genorise® recombinant human P73 protein

GR119119 5 µg
EUR 285

Genorise® recombinant Mouse P73 protein

GR124119 5 µg
EUR 285

p73 (Phospho-Thr86) Polyclonal Conjugated Antibody

C12622 100ul
EUR 476.4

p73 (Phospho-Tyr99) Polyclonal Conjugated Antibody

C11058 100ul
EUR 476.4

p73 (Phospho-Ser388) Polyclonal Conjugated Antibody

C12772 100ul
EUR 476.4

Mouse TP73 (Tumor protein p73) ELISA Kit

ELI-46552m 96 Tests
EUR 1038

Human Tumor Protein p73 (TP73) ELISA Kit

abx595454-96tests 96 tests
EUR 764.4

Rabbit Anti-Human p73 beta antiserum # 3

P73B13-S 100 ul
EUR 548.4

Rabbit Anti-Human p73 alpha antiserum # 2

P73A12-S 100 ul
EUR 548.4

conclusion
Sector RP is a rare form of RP in which only one or two quadrants of the retina display signs of clinical pathology. Most cases are caused by mutations in RHO. These data confirmed earlier reports phenotypic manifestations of RP sector. Low retinal quadrants may be more severely affected because of greater exposure to light.

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