Apexbt

EZ-DNA Reagents

BS8202 100preps
EUR 105.67

Apexbio Reagents Laboratories manufactures the www.apexbt.com reagents distributed by Genprice. The Www.Apexbt.Com reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. To purchase these products, for the MSDS, Data Sheet, protocol, storage conditions/temperature or for the concentration, please contact Apexbio Reagents. Other Www.Apexbt.Com products are available in stock. Specificity: Www.Apexbt.Com Category:

True north Cryobox 0.2mLNatural

PK10
EUR 172.8

True north Cryobox 0.5mLNatural

PK10
EUR 153.6

True north Cryobox1.5/2mLNatural

PK10
EUR 100.8

True north Cryobox 5mLNatural

PK10
EUR 153.6

True north Cryobox 5mLBlue

PK10
EUR 153.6

True north Cryobox 15mLNatural

PK10
EUR 212.4

True north Cryobox 15mLBlue

PK10
EUR 212.4

Human Samples information

Human APEX Nuclease 1 (APEX1) ELISA Kit

RDR-APEX1-Hu-96Tests 96 Tests
EUR 907.2

Mouse APEX Nuclease 1 (APEX1) ELISA Kit

RDR-APEX1-Mu-48Tests 48 Tests
EUR 668.4

Mouse APEX Nuclease 1 (APEX1) ELISA Kit

RDR-APEX1-Mu-96Tests 96 Tests
EUR 928.8

Human APEX Nuclease 2(APEX2)ELISA Kit

QY-E05142 96T
EUR 433.2

Human APEX Nuclease 1(APEX1)ELISA Kit

QY-E05143 96T
EUR 433.2

Human APEX Nuclease 1 (APEX1) ELISA Kit

RD-APEX1-Hu-48T 48T
EUR 452.7
Description: tissue homogenates, cell lysates and other biological fluids.

Human APEX Nuclease 1 (APEX1) ELISA Kit

RD-APEX1-Hu-96T 96T
EUR 646.7
Description: tissue homogenates, cell lysates and other biological fluids.

Mouse APEX Nuclease 1 (APEX1) ELISA Kit

RD-APEX1-Mu-48T 48T
EUR 464.3
Description: tissue homogenates, cell lysates and other biological fluids.

Mouse APEX Nuclease 1 (APEX1) ELISA Kit

RD-APEX1-Mu-96T 96T
EUR 663.3
Description: tissue homogenates, cell lysates and other biological fluids.

Human APEX Nuclease 1 (APEX1) ELISA Kit

RDR-APEX1-Hu-48T 48T
EUR 475.34
Description: tissue homogenates, cell lysates and other biological fluids.

Human APEX Nuclease 1 (APEX1) ELISA Kit

RDR-APEX1-Hu-96T 96T
EUR 679.04
Description: tissue homogenates, cell lysates and other biological fluids.

Mouse APEX Nuclease 1 (APEX1) ELISA Kit

RDR-APEX1-Mu-48T 48T
EUR 487.52
Description: tissue homogenates, cell lysates and other biological fluids.

Mouse APEX Nuclease 1 (APEX1) ELISA Kit

RDR-APEX1-Mu-96T 96T
EUR 696.47
Description: tissue homogenates, cell lysates and other biological fluids.

APE1 Antibody / APEX1

F54484-0.05ML 0.05 ml
EUR 140.25
Description: Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Does also incise at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules. Has a 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER. Possesses a DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate) blocking the 3' side of DNA strand breaks. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'- phosphate (dRp) excision activity of POLB. Plays a role in the protection from granzymes-mediated cellular repair leading to cell death. Also involved in the DNA cleavage step of class switch recombination (CSR). On the other hand, APEX1 also exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR. Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs). Together with HNRNPL or the dimer XRCC5/XRCC6, associates with nCaRE, acting as an activator of transcriptional repression. Stimulates the YBX1-mediated MDR1 promoter activity, when acetylated at Lys-6 and Lys-7, leading to drug resistance. Acts also as an endoribonuclease involved in the control of single-stranded RNA metabolism. Plays a role in regulating MYC mRNA turnover by preferentially cleaving in between UA and CA dinucleotides of the MYC coding region determinant (CRD). In association with NMD1, plays a role in the rRNA quality control process during cell cycle progression. Associates, together with YBX1, on the MDR1 promoter. Together with NPM1, associates with rRNA. Binds DNA and RNA.

APE1 Antibody / APEX1

F54484-0.2ML 0.2 ml
EUR 330.65
Description: Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Does also incise at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules. Has a 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER. Possesses a DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate) blocking the 3' side of DNA strand breaks. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'- phosphate (dRp) excision activity of POLB. Plays a role in the protection from granzymes-mediated cellular repair leading to cell death. Also involved in the DNA cleavage step of class switch recombination (CSR). On the other hand, APEX1 also exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR. Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs). Together with HNRNPL or the dimer XRCC5/XRCC6, associates with nCaRE, acting as an activator of transcriptional repression. Stimulates the YBX1-mediated MDR1 promoter activity, when acetylated at Lys-6 and Lys-7, leading to drug resistance. Acts also as an endoribonuclease involved in the control of single-stranded RNA metabolism. Plays a role in regulating MYC mRNA turnover by preferentially cleaving in between UA and CA dinucleotides of the MYC coding region determinant (CRD). In association with NMD1, plays a role in the rRNA quality control process during cell cycle progression. Associates, together with YBX1, on the MDR1 promoter. Together with NPM1, associates with rRNA. Binds DNA and RNA.

APEX1 Antibody (APE1)

R30567 100 ug
EUR 356.15
Description: APEX1, or Apurinic endonuclease 1 (APE1), which contains probable nuclear transport signals, was identified as a member of a family of DNA repair enzymes found in lower organisms. The abundance of the large form of the protein was increased in leiomyoma extracts relative to myometrial tissue extracts, and the large form was dominant in cell lines derived from leiomyosarcomas. The exonuclease activity of nuclear APEX1 can remove the anti-HIV nucleoside analogs AZT and D4T from the 3-prime terminus of a nick more efficiently than can cytosolic exonucleases.

APE1 Antibody / APEX1

V7287-100UG 100 ug
EUR 349.3
Description: APEX / APE1 is a multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Patients with genetic variants in APEX1 and XRCC1 have been shown to have a higher risk of lung cancer. Elevated APEX1 levels observed in human testicular cancer may be related to relative resistance to therapy and therefore may serve as a diagnostic marker for refractory disease.